Mysterious; not sympathomimetic; may perhaps raise dopamine levels while in the Mind by binding to the dopamine transporter and inhibiting dopamine reuptake
carbamazepine will lower the level or influence of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
Misuse suggests having medication in a way aside from how it absolutely was prescribed. Take modafinil accurately as prescribed. Convey to your healthcare supplier in case you feel that modafinil just isn't Performing.
apalutamide will lower the level or outcome of modafinil by affecting hepatic enzyme CYP2C19 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a powerful CYP2C19 inducer, with prescription drugs which can be CYP2C19 substrates may result in reduced exposure to those remedies.
elvitegravir/cobicistat/emtricitabine/tenofovir DF improves amounts of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
eslicarbazepine acetate will improve the stage or effect of modafinil by impacting hepatic enzyme CYP2C19 metabolism. Use Caution/Observe.
[34] GABA generates a calming and enjoyable effect which is necessary for snooze, and decreased stages are considered to play a task in Modafinil’s eugeroic impact.
fedratinib will enhance the amount or influence of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. Change dose of medicine which might be CYP3A4 substrates as required.
Dizziness and Sleepiness. Modafinil will make you dizzy or sleepy. Will not drive or do other things to do that have to have alertness or coordination until finally you know how modafinil has an effect on you.
etravirine will minimize the level or result of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
However, the waking system of modafinil is still being thoroughly unveiled. Current reports noted that modafinil could possibly be matter to abuse and addiction. Moreover prolonged sleeplessness induces worry responses and impairs immune operate.
Stiripentol is often a CYP3A4 inhibitor and inducer. Observe CYP3A4 substrates more info coadministered with stiripentol for elevated or lessened results. CYP3A4 substrates might call for dosage adjustment.
stiripentol will boost the level or impact of modafinil by impacting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Monitor Intently. Take into consideration reducing the dose of CYP2C19 substrates, if adverse reactions are professional when administered concomitantly with stiripentol.
In the remedy of narcolepsy or snooze apnea, modafinil is mostly prescribed in just one day-to-day dose of 200 mg, to become taken promptly on waking. For Change Function Condition, the suggested dosage is typically two hundred mg, taken a person hour ahead of the commencement in the shift.